Famacogénica del cáncer: Estudio de variaciones genéticamente determinadas en la susceptibilidad a cáncer por exposición a xenobióticos / Cancer pharmacogenetics: Study of genetically determined variations on cancer susceptibility due to xenobiotic exposure
Rev. méd. Chile
; 134(4): 499-515, abr. 2006. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-428552
Responsible library:
BR1.1
ABSTRACT
Pharmacogenetics is the study of genetically determined variations in the response to drugs and toxic agents, and their implications on disease. Recently, the discipline has acquired great relevancy due to the development of non-invasive molecular techniques that identify genetic variants in human beings. There is also a need to explain the individual differences in susceptibility to drug actions and disease risk. Genetic variants can modify the magnitude of a pharmacologic effect, toxicity threshold, secondary effects and drug interactions. There are approximately thirty families of drug-metabolizing enzymes with genetic variants that cause functional alterations and variations in pharmacologic activity. We summarize the general knowledge about genetic variants of biotransformation enzymes, their relationship with cancer risk and the role of ethnicity. Cancer pharmacogenetics is another promising and exciting research area that will explain why people with an almost identical group of genes, have a different susceptibility to cancer, whose etiology has genetic and environmental components.
Full text:
Available
Collection:
International databases
Health context:
SDG3 - Target 3.9 Reduce the amount of deaths produced by dangerous chemicals and the pollution of the air, water and soil
Health problem:
Occupational Exposures
Database:
LILACS
Main subject:
Pharmacogenetics
/
Polymorphism, Genetic
/
Aryl Hydrocarbon Hydroxylases
/
Xenobiotics
/
Genetic Predisposition to Disease
/
Neoplasms
Limits:
Humans
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2006
Document type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Universidad de Chile/CL