Características clínico-moleculares del cáncer gástrico cardial asociado al virus Epstein Barr / Clinical and molecular features of cardial gastric cancer associated to Epstein Barr virus
Rev. méd. Chile
; 133(7): 753-760, jul. 2005. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-429133
Responsible library:
BR1.1
ABSTRACT
Background:
Mortality caused by cardial gastric cancer in Chile, is increasing. Previously we demonstrated an association between Epstein Barr virus and this specific location of gastric cancer.Aim:
To perform a clinical and molecular characterization of cardial gastric cancer associated to Epstein Barr virus. Material andmethods:
Epstein Barr virus was identified in 93 cardial gastric tumors, by in situ hybridization. Clinical and pathological features, survival and expression of p53 and c-erbB2 were compared between tumors with or without the presence of the virus.Results:
Twenty two (23.6%) tumors expressed Epstein Barr virus. No difference in sex or age of patients with tumors positive or negative for the virus was observed. Epstein Barr positive tumors had a tendency to have a higher frequency of Bormann III endoscopic appearance and a lower frequency of p53 accumulation (p=0.06). Five years survival was 67% and 42% of tumors positive and negative for the presence of the virus, respectively (p=0.57).Conclusions:
Our results, although not significant, show a tendency towards unique characteristics of cardial gastric tumors associated to Epstein Barr virus.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Stomach Neoplasms
/
Cardia
/
Epstein-Barr Virus Infections
Type of study:
Prognostic study
/
Risk factors
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Chile
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2005
Document type:
Article
/
Project document
Affiliation country:
Chile
/
Costa Rica
/
Japan
Institution/Affiliation country:
Hospital Clínico San Borja Arriarán/CL
/
Hospital Max Peralta/CR
/
Pontificia Universidad Católica de Chile/CL
/
Universidad de Chile/CL
/
Universidad de Kagoshima/JP