Iron and glutathione at the crossroad of redox metabolism in neurons
Biol. Res
; 39(1): 157-165, 2006. ilus
Article
in English
| LILACS
| ID: lil-430708
Responsible library:
BR1.1
RESUMO
Neurons, as non-dividing cells, encounter a myriad of stressful conditions throughout their lifespan. In particular, there is increasing evidence that iron progressively accumulates in the brain with age and that iron-induced oxidative stress is the cause of several forms of neurodegeneration. Here, we review recent evidence that gives support to the following notions 1) neuronal iron accumulation leads to oxidative stress and cell death; 2) neuronal survival to iron accumulation associates with decreased expression of the iron import transporter DMT1 and increased expression of the efflux transporter IREG1; and 3) the adaptive process of neurons towards iron-induced oxidative stress includes a marked increase in both the expression of the catalytic subunit of gamma glutamate-cysteine ligase and glutathione. These findings may help to understand aging-related neurodegeneration hallmarks oxidative damage, functional impairment and cell death.
Full text:
Available
Collection:
International databases
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Endocrine System Diseases
Database:
LILACS
Main subject:
Oxidative Stress
/
Glutathione
/
Iron
/
Nerve Degeneration
/
Neurons
Limits:
Adult
/
Aged
/
Humans
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2006
Document type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Universidad de Chile/CL