Effects of physical exercise on food intake and body weight: experimental study in tumor-bearing rats
Appl. cancer res
; 26(2): 56-60, Dez. 2006. ilus
Article
in En
| LILACS, Inca
| ID: lil-445858
Responsible library:
BR30.1
ABSTRACT
Cancer cachexia is frequently observed in tumor-bearing patients or animals with diabetes-like syndrome. Physical exercise has been shown to reduce insulin requirements in diabetics. Objectives:
To evaluate the effects of daily physical exercise on foodintake and body weight in an experimental tumor-bearing rat model (Walker 256 carcinosarcoma).Methods:
Wistar adult rats were submitted to a similar daily manipulation protocol except for physical exercise (running pad continuously for 60 minutes/day), and randomly distributed as to the presence of tumor or exercise into eight groups Group 1 (Saline day 1 + No exercise for 50 days), Group 2 (Tumor day 1 + No exercise for 50 days), Group 3 (Saline day 1 + Exercise for 50 days), Group 4 (Tumor day 1 + Exercise for 50 days), Group 5 (Tumor day 1 + Exercise for 25 days + No exercise for following 25 days), Group6 (Tumor day 1 + No exercise for 25 days + Exercise for following 25 days), Group 7 (Exercise for 25 days + Tumor day 25 + Exercise for following 25 days), Group 8 (Exercise for 25 days + Saline day 25 + Exercise for following 25 days).Results:
Body weight was significantly lower in Exercise (mean coefficient 1.29 ± 0.17), than in No exercise (mean coefficient 2.2 ± 0.16) - p<0.001. In the tumor-bearing rats, exercise did not affect significantly daily food intake - p=0.415.Conclusions:
Daily physical exercise significantly affected body weight in this animal model, but did not have impact on food intake.
Full text:
1
Collection:
01-internacional
Database:
LILACS
/
Inca
Main subject:
Body Weight
/
Cachexia
/
Exercise
/
Data Interpretation, Statistical
/
Neoplasms
Limits:
Animals
Language:
En
Journal:
Appl. cancer res
Journal subject:
NEOPLASIAS
Year:
2006
Document type:
Article
Affiliation country:
Brazil
Country of publication:
Brazil