Stereological study of collagen and elastic system in the detrusor muscle of bladders from controls and patients with infravesical obstruction
Int. braz. j. urol
; 33(1): 33-41, Jan.-Feb. 2007. ilus, tab
Article
in English
| LILACS
| ID: lil-447464
Responsible library:
BR1.1
ABSTRACT
OBJECTIVE:
Compare detrusor muscle of normal and patients with infravesical obstruction, quantifying the collagen and elastic system fibers. MATERIALS ANDMETHODS:
We studied samples taken from bladders of 10 patients whose ages ranged from 45 to 75 years (mean = 60 years), who underwent transvesical prostatectomy for treatment of BPH. Control material was composed of 10 vesical specimens, removed during autopsies performed in cadavers of accident victims, with ages between 18 and 35 years (mean = 26 years).RESULTS:
The results of collagen and elastic fibers quantification (volumetric density) demonstrated the following results in percentage (mean +/- standard deviation) collagen in BPH patients = 4.89 +/- 2.64 and 2.32 +/- 1.25 in controls (p < 0.0001), elastin in BPH patients = 10.63 percent +/- 2.00 and 8.94 percent +/- 1.19 in controls (p < 0.0001).CONCLUSION:
We found that the components of connective tissue, collagen and elastic system fibers are increased in the detrusor muscle of patients with infravesical obstruction, when compared to controls.
Full text:
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Collection:
International databases
Database:
LILACS
Main subject:
Prostatic Hyperplasia
/
Urinary Bladder Neck Obstruction
/
Collagen
/
Elastic Tissue
/
Muscle Hypertonia
/
Muscle, Smooth
Type of study:
Observational study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Humans
/
Male
Language:
English
Journal:
Int. braz. j. urol
Journal subject:
Urology
Year:
2007
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
State University of Rio de Janeiro/BR