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Merozoite surface protein 2 allelic variation influences the specific antibody response during acute malaria in individuals from a Brazilian endemic area
Sallenave-Sales, Selma; Faria, Clarissa Perez; Zalis, Mariano Gustavo; Daniel-Ribeiro, Cláudio Tadeu; Ferreira-da-Cruz, Maria de Fátima.
Affiliation
  • Sallenave-Sales, Selma; Fiocruz. Instituto Oswaldo Cruz. Rio de Janeiro. BR
  • Faria, Clarissa Perez; Fiocruz. Instituto Oswaldo Cruz. Rio de Janeiro. BR
  • Zalis, Mariano Gustavo; UFRJ. Hospital Universitário Clementino Fraga. Departamento de Medicina Preventiva. Rio de Janeiro. BR
  • Daniel-Ribeiro, Cláudio Tadeu; Fiocruz. Instituto Oswaldo Cruz. Rio de Janeiro. BR
  • Ferreira-da-Cruz, Maria de Fátima; Fiocruz. Instituto Oswaldo Cruz. Rio de Janeiro. BR
Mem. Inst. Oswaldo Cruz ; 102(3): 421-425, June 2007. tab, ilus
Article in En | LILACS | ID: lil-452522
Responsible library: BR1.1
ABSTRACT
The antibody response to Plasmodium falciparum parasites of naturally infected population is critical to elucidate the role of polymorphic alleles in malaria. Thus, we evaluated the impact of antigenic diversity of repetitive and family dimorphic domains of the merozoite surface protein 2 (MSP-2) on immune response of 96 individuals living in Peixoto de Azevedo (MT-Brazil), by ELISA using recombinant MSP-2 proteins. The majority of these individuals were carrying FC27-type infections. IgG antibody responses were predominantly directed to FC27 parasites and were correlated to the extension of polymorphism presented by each MSP-2 region. This finding demonstrated the impact of the genetic polymorphism on antibody response and therefore, its importance on malaria vaccine efficacy.
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Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Plasmodium falciparum / Antibodies, Protozoan / Protozoan Proteins / Malaria, Falciparum / Antibody Specificity / Antigens, Protozoan Limits: Animals / Humans Country/Region as subject: America do sul / Brasil Language: En Journal: Mem. Inst. Oswaldo Cruz Journal subject: MEDICINA TROPICAL / PARASITOLOGIA Year: 2007 Document type: Article Affiliation country: Brazil Country of publication: Brazil
Fulltext
Add to My VHL
Print
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Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Plasmodium falciparum / Antibodies, Protozoan / Protozoan Proteins / Malaria, Falciparum / Antibody Specificity / Antigens, Protozoan Limits: Animals / Humans Country/Region as subject: America do sul / Brasil Language: En Journal: Mem. Inst. Oswaldo Cruz Journal subject: MEDICINA TROPICAL / PARASITOLOGIA Year: 2007 Document type: Article Affiliation country: Brazil Country of publication: Brazil