Perfil de susceptibilidad a los antimicrobianos en cepas de E coli productoras de Shiga toxina (STEC) aisladas de infecciones humanas y de alimentos / Antimicrobial susceptibility of shiga toxin producing E coli (STEC) strains isolated from human infections and food
Rev. méd. Chile
; 132(10): 1211-1216, oct. 2004. tab
Article
in Spanish
| LILACS
| ID: lil-453996
Responsible library:
BR1.1
ABSTRACT
BACKGROUND:
Shiga toxin-producing E coli (STEC) are zoonotic pathogens associated to sporadic episodes of bloody diarrhea, foodborne outbreaks, and Hemolytic Uremic Syndrome (HUS), with worldwide public health impact. Antibiotic use in STEC infections is controversial because of the potential to increase production and secretion of Shiga toxins.AIM:
To study the in vitro antimicrobial susceptibility profile of STEC. MATERIAL ANDMETHODS:
The in vitro susceptibility profile against 10 antimicrobials of STEC strains isolated from 29 meat products, 20 patients with diarrhea and 9 HUS patients was studied. Minimal Inhibitory Concentrations (microg/ml) by agar dilution method for ampicillin, cloramphenicol, ciprofloxacin, amikacin, gentamycin, cotrimoxazol, ceftriaxone, tetracycline, fonsfomycin and azihromycin were measured according to NCCLS recommendations.RESULTS:
Strains from patients with diarrhea or HUS were all susceptible to the 10 antimicrobials and only 13.7% had intermediate resistance to cloramphenicol. Strains from meat products had a similar susceptibility profile, with only 3.5% resistance to tetracycline, 3.5% intermediate resistance to cloramphenicol and 7% to fosfomycin. All 58 strains were considered resistant to azithromycin (MIC >32 microg/ml).CONCLUSIONS:
Similarity of susceptibility profiles between STEC strains from human and food origin suggests a role of food chain in transmission to humans.
Full text:
Available
Collection:
International databases
Health context:
Neglected Diseases
Health problem:
Diarrhea
/
Neglected Diseases
/
Zoonoses
Database:
LILACS
Main subject:
Shiga Toxins
/
Drug Resistance, Bacterial
/
Escherichia coli
/
Anti-Bacterial Agents
Limits:
Humans
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2004
Document type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Universidad de Chile/CL