Estudo dos efeitos da fluoxetina e da venlafaxina no comportamento alimentar compulsivo do tipo binge em ratos / Study of fluxetine and venlafaxine effects in binge-eating in rats
Arq. méd. ABC
; 29(1): 49-53, jan.-jun. 2004. ilus, tab
Article
in Pt
| LILACS
| ID: lil-457902
Responsible library:
BR1342.1
RESUMO
Objetivo:
Avaliar a eficácia da fluoxetina e venlafaxina no tratamento do comportamento alimentar compulsivo tipo binge induzido por restrição de espaço, em ratos. Material emétodo:
Foram utilizados 120 ratos, subdivididos em grupos de acordo com a droga utilizada (controle, fluoxetina ou venlafaxina), os tipos de alimentação (dieta livre ou regrada) e gaiolas utilizadas (tamanho padrão ou de espaço restrito) .Resultados:
Os ratos mostraram hiperfagia rebote quando foram submetidos à dieta restrita (2 horas/dia por 7 dias). A hiperfagia foi aumentada quando os ratos foram colocados na gaiola de espaço restrito, tendo sua mobilidade diminuída. Apenas o grupo em que foi administrada venlafaxina apresentou diminuição do binge pela restrição de espaço.Conclusão:
O tratamento com fluoxetina foi incapaz de alterar o comportamento do tipo binge induzido em ratos, já a venlafaxina, sob as mesmas condições, reduziu este comportamento.ABSTRACT
Background:
studies have suggested that people who suffer from bulimia nervosa show signs of reduced serotonin activity, which may be related to binge-eating.Objective:
to evaluate fluoxetine and venlafaxine efficacy in treatment of binge eating induced byspace restriction in rats. Methods and materials Were studied 120 rats, divided according to the administrated drug (control, fluoxetine or venlafaxine), feeding types (free feeding or scheduled feeding) and cages (home cages or space-restricted cages).Results:
the rats showed rebound hyperphagic state when they were released from scheduled feeding. The hyperphagia was further enhancedwhen they were put in a space-estricted cage where their mobility was restricted. Only the group that received venlafaxine showed decrease in binge eating induced by space restriction.Conclusion:
the treatment with fluoxetine was enable to change the binge eating in rats, however venlafaxine, at same conditions, reduced this behaviour.
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Hyperphagia
/
Fluoxetine
/
Rats, Wistar
/
Compulsive Behavior
/
Feeding Behavior
/
Antidepressive Agents
Limits:
Animals
Language:
Pt
Journal:
Arq. méd. ABC
Journal subject:
MEDICINA
Year:
2004
Document type:
Article
Affiliation country:
Brazil
Country of publication:
Brazil