Inclusion complex of S(-) bupivacaine and 2-hydroxypropyl-beta-cyclodextrin: study of morphology and cytotoxicity
Rev. ciênc. farm. básica apl
; 27(3): 207-212, 2006. ilus, graf
Article
in English
| LILACS
| ID: lil-466202
Responsible library:
BR33.1
ABSTRACT
Local anesthetics (LA) belong to a class of pharmacological compounds that attenuate or eliminate pain by binding to the sodium channel of excitable membranes, blocking the influx of sodium ions and the propagation of the nerve impulse. S (-) bupivacaine (S(-)bvc) is a local anesthetic of amino-amide type, widely used in surgery and obstetrics for sustained peripheraland central nerve blockade. This article focuses on the characterization of an inclusion complex of S(-) bvc in2-hydroxypropyl- beta-cyclodextrin (HP-beta -CD). Differential scanning calorimetry, scanning electron microscopy andX-Ray diffraction analysis showed structural changes inthe complex. In preliminary toxicity studies, the cellviability tests revealed that the inclusion complex decreased the toxic effect (p smaller that 0.001) produced by S(-) bvc.These results suggest that the S(-) bvcHP- beta-CD inclusion complex represents a promising agent for the treatment of regional pain.
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Collection:
International databases
Database:
LILACS
Main subject:
Pain
/
Bupivacaine
/
Calorimetry, Differential Scanning
/
Microscopy, Electron, Scanning
/
Inclusion Bodies
/
Beta-Cyclodextrins
Language:
English
Journal:
Rev. ciênc. farm. básica apl
Journal subject:
Pharmacology
Year:
2006
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Federal University of Paraná/BR
/
State University of Campinas/BR
/
University of Sorocaba/BR
/
University of São Paulo/BR