The ingestión of a Nectandra membran cea extract changes the bioavailability of technetium-99m radiobiocomplex in rat organs

ABSTRACT

The radiobiocomplexes labeled with technetium-99m (Tc-99m) have been widely used in nuclear medicine in single photon emission computed tomography and in basic research. The aim of this study was to assess the influence of a Nectandra membran cea extract on the bioavailability of the sodium pertechnetate (Na99mTc0(4)) radiobiocomplex in rat organs. The animals were treated with a N. membran cea extract (30 mg/ ml), for 6 days. Na99mTc0(4) was injected, the organs were isolated and weighed, and the radioactivity was determined in each organ ( percentATI/organ). The percentATI/organ was divided by the mass of each organ to calculate the percentATI/g. A significant increase of the percentATI/organ of Na99mTc0(4) was observed in muscle and thyroid as well as in the percentATI/g in the heart, kidney and thyroid. These findings could result from the interaction between components of the plant extract and the radiobiocomplex which may influence the uptake Na99mTc0(4) in rat organs. Therefore, precaution is suggested in the interpretation of nuclear medicine results in patients using this herb.