Occurrence of pneumocystis pneumonia in hiv-infected patients and the interference of the highly active antiretroviral therapy
J. venom. anim. toxins incl. trop. dis
; 14(1): 152-160, 2008. graf, tab
Article
in En
| LILACS
| ID: lil-479346
Responsible library:
BR33.1
ABSTRACT
From the beginning of the AIDS epidemic, pneumocystis pneumonia (PCP) has been distinguished as one of the most frequent opportunistic diseases with high morbid-mortality. As from 1996, the advent of the highly active antiretroviral therapy (HAART) has changed the characteristics of such epidemic by reducing its related diseases and, as a result, AIDS-related mortality. With the purpose to estimate PCP occurrence and HAART interference, 376 HIV-infected or AIDS patients were studied from January 1992 to December 2002. Among them, 58 (15.5 percent) PCP cases were found. There was a higher occurrence of PCP in the group of patients in which HAART was not used, with 40 (69.0 percent) of the episodes. As regards the studied period, a tendency to a linear reduction in annual PCP incidence was observed. The mean of T CD4+ lymphocytes in the patients with PCP (117 cells/mm³) was significantly lower when compared to that of the other individuals (325 cells/mm³). Therefore, this study suggests a temporal reduction in PCP occurrence related to HAART use with higher T CD4+ lymphocyte counts. Nevertheless, this opportunistic infection still shows significant incidence in AIDS patients. (NCT00516581).
Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Pneumonia, Pneumocystis
/
HIV Infections
/
AIDS-Related Opportunistic Infections
/
Antiretroviral Therapy, Highly Active
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
J. venom. anim. toxins incl. trop. dis
Journal subject:
TOXICOLOGIA
Year:
2008
Document type:
Article
Affiliation country:
Brazil
Country of publication:
Brazil