Antagonism of morphine-induced central respiratory depression by donepezil in the anesthetized rabbit
Biol. Res
; 40(3): 339-346, 2007. graf
Article
in En
| LILACS
| ID: lil-481311
Responsible library:
BR1.1
ABSTRACT
Morphine is often used in cancer pain and postoperative analgesic management but induces respiratory depression. Therefore, there is an ongoing search for drug candidates that can antagonize morphine-induced respiratory depression but have no effect on morphine-induced analgesia. Acetylcholine is an excitatory neurotransmitter in central respiratory control and physostigmine antagonizes morphine-induced respiratory depression. However, physostigmine has not been applied in clinical practice because it has a short action time, among other characteristics. We therefore asked whether donepezil (a long-acting acetylcholinesterase inhibitor used in the treatment of Alzheimer's disease) can antagonize morphine-induced respiratory depression. Using the anesthetized rabbit as our model, we measured phrenic nerve discharge as an index of respiratory rate and amplitude. We compared control indices with discharges after the injection of morphine and after the injection of donepezil. Morphine-induced depression of respiratory rate and respiratory amplitude was partly antagonized by donepezil without any effect on blood pressure and end-tidal C0(2). In the other experiment, apneic threshold PaC0(2) was also compared. Morphine increased the phrenic nerve apnea threshold but this was antagonized by donepezil. These findings indicate that systemically administered donepezil partially restores morphine-induced respiratory depression and morphine-deteriorated phrenic nerve apnea threshold in the anesthetized rabbit.
Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Piperidines
/
Respiration
/
Cholinesterase Inhibitors
/
Indans
/
Morphine
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Biol. Res
Journal subject:
BIOLOGIA
Year:
2007
Document type:
Article
Affiliation country:
Japan
Country of publication:
Chile