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In vivo effects of Buthus occitanus tunetanus and Androctonus australis garzoni scorpion venoms on pregnant and non-pregnant rats
Hmed, B. N; Serria, H. T; Selma, C; Zouheir, S; Tarek, R; Mondher, K; Zakaria, B; Mounir, Z. K.
Affiliation
  • Hmed, B. N; University of Sfax. Sfax Faculty of Medicine. Laboratory of Pharmacology. Sfax. TN
  • Serria, H. T; University of Sfax. Sfax Faculty of Medicine. Laboratory of Pharmacology. Sfax. TN
  • Selma, C; University of Sfax. Sfax Faculty of Medicine. Laboratory of Pharmacology. Sfax. TN
  • Zouheir, S; University of Sfax. Sfax Faculty of Medicine. Laboratory of Pharmacology. Sfax. TN
  • Tarek, R; University of Sfax. Sfax Faculty of Medicine. Laboratory of Pharmacology. Sfax. TN
  • Mondher, K; Service of Communitarian Medicine and Epidemiology. Sfax. TN
  • Zakaria, B; Pasteur Institute of Tunis. Tunis. TN
  • Mounir, Z. K; University of Sfax. Sfax Faculty of Medicine. Laboratory of Pharmacology. Sfax. TN
J. venom. anim. toxins incl. trop. dis ; 14(2): 366-371, 2008. tab
Article in English | LILACS, VETINDEX | ID: lil-484571
Responsible library: BR68.1
ABSTRACT
Scorpion envenomation in pregnant victims has been scarcely studied. Accidents with venomous animals can induce serious injuries for both mothers and embryos. In the current work, the lethality of Buthus occitanus tunetanus (Bot) and Androctonus australis garzoni (Aag) venoms was assessed in pregnant and non-pregnant murine rat models. The median lethal dose (LD50) was determined following the Spearman-Karber method. Our results showed great similarities of envenomation symptoms between term-pregnant and nonmated rats. An unusual vaginal bleeding was also seen in pregnant rats envenomed with Bot and Aag venoms. Our findings suggest that gestation may increase the venoms toxicity in rats.(AU)
Subject(s)

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Full text: Available Database: LILACS / VETINDEX Main subject: Scorpion Venoms / Scorpion Stings / Lethal Dose 50 Type of study: Prognostic study Limits: Animals / Pregnancy Language: English Journal: J. venom. anim. toxins incl. trop. dis Year: 2008 Document type: Article Institution/Affiliation country: Pasteur Institute of Tunis/TN / Service of Communitarian Medicine and Epidemiology/TN / University of Sfax/TN
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Full text: Available Database: LILACS / VETINDEX Main subject: Scorpion Venoms / Scorpion Stings / Lethal Dose 50 Type of study: Prognostic study Limits: Animals / Pregnancy Language: English Journal: J. venom. anim. toxins incl. trop. dis Year: 2008 Document type: Article Institution/Affiliation country: Pasteur Institute of Tunis/TN / Service of Communitarian Medicine and Epidemiology/TN / University of Sfax/TN