Inflamación y disfunción endotelial en pacientes con insuficiencia cardiaca crónica / Inflammation and endothelial dysfunction in patients with chronic heart failure
Rev. méd. Chile
; 136(6): 687-693, jun. 2008. graf, tab
Article
in Es
| LILACS
| ID: lil-490752
Responsible library:
BR1.1
ABSTRACT
Background:
In chronic heart failure (CHF), endothelial dysfunction (ED) is a consequence of an imbalance of vascular tone regulating substances. The relationship between ED and inflammation has not been fully investigated.Aim:
To assess the association between inflammation and ED in CHF. Material andmethods:
Forty two patients aged 56±14 years (80 percent male) with a CHF in functional capacity II-III (New York Heart Association) and an ejection fraction (FE) <40 percent were consecutively studied. Patients were classified according to the presence or absence of ED, evaluated by reactive vasodilation measured by ultrasound, after brachial artery compression. Circulating levels of highly sensitive C reactive protein (usCRP), tumor necrosis factor a (TNFá) and interleukin-6 (IL-6) were determined by ELISA. A group of 15 healthy subjects of similar age, were studied as controls.Results:
Sixty seven percent of patients had ED. Compared to controls, patients with CHF had higher usCRP (0.58±0.4 and 4.9±7.1 mg/dl respectively, p <0.01) and IL-6 (1.38±0.06 and 3.1±1.7 mg/dl respectively, p <0.01). Compared to patients without ED, patients with CHF and ED had higher levéis of usCRP (3.0±0.4 and 6.0±5.7 mg/dl respectively, p <0.01) and TNFá (0.31±0.26 and 1.0±1.1 pg/ml, p =0.02). No differences in IL-6 were found between CHF groups.Conclusions:
In CHF patients, the presence of ED was associated with increased levéis of inflammatory markers.Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Endothelium, Vascular
/
Heart Failure
/
Inflammation
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Es
Journal:
Rev. méd. Chile
Journal subject:
MEDICINA
Year:
2008
Document type:
Article
/
Project document
Affiliation country:
Chile
Country of publication:
Chile