Anti-flagellin antibody responses elicited in mice orally immunized with attenuated Salmonella enterica serovar Typhimurium vaccine strains
Mem. Inst. Oswaldo Cruz
; 103(6): 606-610, Sept. 2008. graf, tab, ilus
Article
in English
| LILACS, Sec. Est. Saúde SP
| ID: lil-495738
Responsible library:
BR1.1
ABSTRACT
In the present study we investigated the flagellin-specific serum (IgG) and fecal (IgA) antibody responses elicited in BALB/c mice immunized with isogenic mutant derivatives of the attenuated Salmonella enterica serovar Typhimurium (S. Typhimurium) SL3261 strain expressing phase 1 (FliCi), phase 2 (FljB), or no endogenous flagellin. The data reported here indicate that mice orally immunized with recombinant S. Typhimurium strains do not mount significant systemic or secreted antibody responses to FliCi, FljB or heterologous B-cell epitopes genetically fused to FliCi. These findings are particularly relevant for those interested in the use of flagellins as molecular carriers of heterologous antigens vectored by attenuated S. Typhimurium strains.
Full text:
Available
Collection:
National databases
/
Brazil
Health context:
Neglected Diseases
Health problem:
Neglected Diseases
/
Zoonoses
Database:
LILACS
/
Sec. Est. Saúde SP
Main subject:
Salmonella typhimurium
/
Salmonella Vaccines
/
Flagellin
/
Antibodies, Bacterial
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Year:
2008
Document type:
Article
Institution/Affiliation country:
Instituto Butantan/BR
/
Universidade de São Paulo/BR
/
University of Oklahoma/US