Polimorfismos genéticos del transportador de serotonina (SERT) y depresión / Serotonin transporter gene polymorphisms (SERT) and depression
Trastor. ánimo
; 2(1): 6-12, ene.-jun. 2006. ilus
Article
in Spanish
| LILACS
| ID: lil-499032
Responsible library:
CL15.1
ABSTRACT
Genetic studies on depression have focused on the polimorphisms of the serotonin system genes. It has been investigated the tryptophan hydroxylase and the serotonin receptor genes, specifically the serotonin transporter. Two alleles of the promoter for the serotonin transporter gene have been described a long allele (L) and a short allele (S). Studies suggest that the presence of the short allele (S) is associated to a higher vulnerability for depression in the presence of adverse environmental factors. By the other hand, the presence of the long allele (L) gives resilience for stressful situations. It is believed that the acquisition of higher vulnerability for stress must occur during early stages of neurodevelopment.
RESUMEN
Los estudios genéticos en depresión se han enfocado especialmente en los polimorfismos de los genes asociados al sistema serotoninérgico. Se han investigado los genes de la triptofano hidroxilasa, de algunos receptores de serotonina y particularmente del transportador de serotonina. Se han descrito dos alelos en la región promotora del transportador de serotonina uno largo (L) y otro corto (S). Los estudios sugieren que la presencia del alelo corto (S) se asocia a una mayor vulnerabilidad a la depresión en presencia de factores ambientales adversos. A la inversa, la presencia del alelo largo (L) parece conferir resiliencia frente a las situaciones de estrés. Se cree que la adquisición de la mayor vulnerabilidad al estrés debe ocurrir en etapas tempranas del neurodesarrollo.
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Collection:
International databases
Database:
LILACS
Main subject:
Polymorphism, Genetic
/
Depression
/
Dopamine Plasma Membrane Transport Proteins
Limits:
Humans
Language:
Spanish
Journal:
Trastor. ánimo
Journal subject:
Psychology
Year:
2006
Document type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Universidad de Chile/CL