MTHFR, prothrombin and Factor V gene variants in Turkish patients with coronary artery stenosis
Genet. mol. biol
; 31(4): 836-838, Sept.-Dec. 2008. tab
Article
in English
| LILACS
| ID: lil-501465
Responsible library:
BR26.1
ABSTRACT
Many epidemiological studies have reported an association between hemostatic factors and risk of both coronary and peripheral artery diseases. Using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis, we investigated the association between coronary artery disease and polymorphisms in the methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), prothrombin (G20210A), and factor V (A4070G) genes. We screened these gene variants in 174 subjects who had undergone coronary angiography - 115 patients with patent coronary artery disease (grade 3 vessel disease, i.e., significant coronary stenosis), and 59 healthy controls with grade 0 vessel disease. The analysis of our data did not show any statistically significant association between coronary artery disease (CAD) and the investigated polymorphisms.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Factor V
/
Prothrombin
/
Coronary Stenosis
Type of study:
Etiology study
/
Risk factors
Limits:
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Genet. mol. biol
Journal subject:
Genetics
Year:
2008
Document type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
Maltepe University/TR
/
Marmara University/TR
/
Namik Kemal University/TR
/
Safak Hospital/TR