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Invasive aspergillosis in hematopoietic stem cell transplant recipients: a retrospective analysis
Carvalho-Dias, Viviane Maria Hessel; Sola, Caroline Bonamin Santos; Cunha, Clóvis Arns da; Shimakura, Sílvia Emiko; Pasquini, Ricardo; Queiroz-Telles, Flávio de.
Affiliation
  • Carvalho-Dias, Viviane Maria Hessel; Federal University of Parana. Hospital de Clinicas. Curitiba. BR
  • Sola, Caroline Bonamin Santos; Federal University of Parana. Hospital de Clinicas. Curitiba. BR
  • Cunha, Clóvis Arns da; Federal University of Parana. Hospital de Clinicas. Curitiba. BR
  • Shimakura, Sílvia Emiko; Federal University of Parana. Statistics and Geo-Information Laboratory. Curitiba. BR
  • Pasquini, Ricardo; Federal University of Parana. Hospital de Clinicas. Curitiba. BR
  • Queiroz-Telles, Flávio de; Federal University of Parana. Hospital de Clinicas. Curitiba. BR
Braz. j. infect. dis ; 12(5): 385-389, Oct. 2008. graf, tab
Article in English | LILACS | ID: lil-505351
Responsible library: BR1.1
ABSTRACT
Invasive aspergillosis (IA) currently is an important cause of mortality in subjects undergoing hematopoietic stem cell transplants (HSCT) and is also an important cause of opportunistic respiratory and disseminated infections in other types of immunocompromised patients. We examined the medical records of 24 cases of proven and probable invasive aspergillosis (IA) at the Hospital de Clinicas of the Federal University of Parana, Brazil, from January 1996 to October 2006. During this period occurred a mean of 2.2 cases per year or 3.0 cases per 100 HSTC transplants. There was a significant relationship between structural changes in the bone marrow transplant (BMT) Unit and the occurrence of IA cases (p=0.034, relative risk (RR) = 2.47). Approximately 83 percent of the patients died due to invasive fungal infection within 60 days of follow up. Some factors tended to be associated with mortality, but these associations were not significant. These included corticosteroid use, neutropenia (<100 cells/mm³) at diagnosis, patients that needed to change antifungal therapy because of toxicity of the initial first-line regimen and disseminated disease. These factors should be monitored in BMT units to help prevent IA. Physicians should be aware of the risk factors for developing invasive fungal infections and try to reduce or eliminate them. However, once this invasive disease begins, appropriate diagnostic and treatment measures must be implemented as soon as possible in order to prevent the high mortality rates associated with this condition.
Subject(s)

Full text: Available Collection: International databases Database: LILACS Main subject: Aspergillosis / Immunocompromised Host / Hematopoietic Stem Cell Transplantation Type of study: Diagnostic study / Etiology study / Observational study Limits: Adolescent / Adult / Child / Humans Country/Region as subject: South America / Brazil Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2008 Document type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Parana/BR
Full text: Available Collection: International databases Database: LILACS Main subject: Aspergillosis / Immunocompromised Host / Hematopoietic Stem Cell Transplantation Type of study: Diagnostic study / Etiology study / Observational study Limits: Adolescent / Adult / Child / Humans Country/Region as subject: South America / Brazil Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2008 Document type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Parana/BR
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