Pseudomonas aeruginosa infections: factors relating to mortality with emphasis on resistance pattern and antimicrobial treatment
Braz. j. infect. dis
; 12(6): 509-515, Dec. 2008. tab
Article
in English
| LILACS
| ID: lil-507452
Responsible library:
BR1.1
ABSTRACT
A retrospective case-control study was conducted to investigate the risk factors for death among intensive care unit patients with Pseudomonas aeruginosa infection. Out of 131 patients investigated, 67 (51.1 percent) died within 30 days of being diagnosed with this infection. The mean duration of hospital stay before this diagnosis was 28.5 ± 26.5 days. No association was found between bacterial resistance and death in this study (multiresistant p= 0.26; panresistant p= 0.42), but the adequacy of the initial treatment was inversely proportional to the degree of resistance. There was a tendency towards greater mortality among patients who received combination therapy (empirical p= 0.09; definitive p= 0.08), despite the greater frequency of appropriate treatment in these patients and the similar degree of severity in the two groups. This finding may be explained by pharmacodynamic parameters that were not studied or by the extensive use of aminoglycosides in the combination therapy, which play a controversial role in combination therapy due to their potential for renal toxicity. The multivariate analysis in our study demonstrated that age [odds ratio (OR) 1.04], septic shock (OR 15.4) and hypoalbuminemia (OR 0.32) were independent risk factors for death.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Pseudomonas Infections
/
Anti-Bacterial Agents
Type of study:
Observational study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Braz. j. infect. dis
Journal subject:
Communicable Diseases
Year:
2008
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Federal University of Pernambuco/BR
/
Hospital Prontolinda/BR