Preparation and antitubercular activity of lipophilic diamines and amino alcohols
Mem. Inst. Oswaldo Cruz
; 104(5): 703-705, Aug. 2009. ilus, tab
Article
in English
| LILACS
| ID: lil-528076
Responsible library:
BR1.1
ABSTRACT
A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 µg/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 µg/mL.
Full text:
Available
Collection:
International databases
Health context:
Neglected Diseases
Health problem:
Neglected Diseases
/
Tuberculosis
Database:
LILACS
Main subject:
Diamines
/
Amino Alcohols
/
Mycobacterium tuberculosis
/
Antitubercular Agents
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2009
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Fiocruz/BR
/
Universidade Federal de Juiz de Fora/BR