Trastuzumab no câncer de mama / Trastuzumab in breast cancer
Femina
; 38(2)fev. 2010. tab
Article
in Portuguese
| LILACS
| ID: lil-545682
Responsible library:
BR1365.1
RESUMO
O trastuzumab, anticorpo monoclonal contra o sítio extracelular do receptor do fator de crescimento epidérmico humano tipo 2 (HER2), vem tendo crescente utilização no tratamento do câncer de mama, promovendo melhora nos resultados e se firmando como opção terapêutica de impacto para pacientes que apresentam tumores HER2 positivo. Aproximadamente 20 a 30% dos carcinomas de mama apresentam superexpressão e/ou amplificação do gene HER2. Tal fato confere comportamento tumoral mais agressivo e piora no prognóstico das pacientes acometidas. Este artigo revisa dados sobre a utilização clínica e a eficácia do trastuzumab no tratamento do câncer de mama inicial e avançado
ABSTRACT
Trastuzumab, a monoclonal antibody against the extracellular domain of the human epidermal growth factor receptor type 2 (HER2), has been increasingly used in breast cancer treatment, improving the outcomes and becoming established as a therapeutic option of impact for patients who express HER2 positive tumors. Approximately 20 to 30% of breast carcinomas present over-expression and/or amplification of the HER2 gene. This fact attributes a more aggressive tumoral behavior and a worsening prognostic of the affected patients. This article reviews data on the clinical usage and efficacy of trastuzumab in the both early and advanced breast cancer treatment
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Breast Neoplasms
/
Treatment Outcome
/
Neoadjuvant Therapy
/
ErbB Receptors
/
Antibodies, Monoclonal
/
Antineoplastic Agents
Type of study:
Prognostic study
Language:
Portuguese
Journal:
Femina
Journal subject:
Gynecology
/
Obstetrics
Year:
2010
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Especialista em Mastologia, Ginecologia e Obstetrícia; Membro do Serviço de Mastologia da Santa Casa de Misericórdia de Lavras/BR