Clinical outcome of patients with relapsed/refractory acute leukemia treated with FLAG-IDA regimen
Hematología (B. Aires)
; 13(2): 49-52, mayo-ago. 2009. tab, graf
Article
in English
| LILACS
| ID: lil-547257
Responsible library:
AR67.1
ABSTRACT
Background:
Patients with Refractory/Relapsed (RIR) acute leukemia (AL) have a poor prognosis.Objective:
We aimed to evaluate the chemotherapy regimen fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin (FLAG-IDA) in patients with RIR AL. Patients We studied 33 patients with R/R AL. Distribution of the AL subtype was myeloblastic n=17 (52%), lymphoblastic n=14 (42%),) and biphenotypic n=2 (6%).Results:
Complete remission (CR) was achieved in 15 cases (45.5%) and seven patients dead resulting in a mortality of 21.1%. In patients with hematological recovery the median time to neutrophils recovery (> 0.5 x 10º/1) was 24 days (range 10-38); platelet levels of more than 20 x 1Oº/l and 50 x 10º/1 were reached in a median time of 24 (range 17-44) and 27 days (range 18-51), respectively. After CR, five patients underwent allogeneic transplan- tation and 10 patients received a second course of FLAG IDA. Ten out of 15 patients who achieved CR with FLAG-IDA relapsed at a median of 7.7 months (95% CI 1.8 to 13.6 months). Overall survival (OS) after FLAG-IDA in the surviving cohort had a median of 4 months. We found a significantly better OS in patients who received allogeneic transplantation post-FLAG-IDA than those who did not (median 11.4 months vs. 2.7 monthsj HR 0.29; 95% CI 0.1 to 0.6; p=0.017).Conclusions:
In our series, FLAG-IDA demonstrated to be an effective salvage chemotherapy regimen, however, the benefit in survival of this rescue treatment was restrained to patients who unde.rwent al1ogeneic transplantation
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Collection:
International databases
Database:
LILACS
Main subject:
Transplantation
/
Leukemia
Type of study:
Prognostic study
Language:
English
Journal:
Hematología (B. Aires)
Journal subject:
Hematology
Year:
2009
Document type:
Article
Affiliation country:
Argentina
Institution/Affiliation country:
Hospital Privado Centro Médico de Córdoba/AR
/
ITMO Hospital Italiano/AR