Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni)
Mem. Inst. Oswaldo Cruz
; 105(4): 387-390, July 2010. ilus
Article
in English
| LILACS
| ID: lil-554802
Responsible library:
BR1.1
ABSTRACT
Here, we observed the uptake of membrane-impermeant molecules by cercariae as they penetrate the skin and are transformed into schistosomula. We propose that membrane-impermeant molecules, Lucifer Yellow, Propidium iodide and Hoechst 33258 enter the parasite through both thenephridiopore and the surface membrane and then diffuse throughout the body of the parasite. We present a hypothesis that the internal cells of the body of the schistosomulum represent a new host-parasite interface, at which skin-derived growth factors may stimulate receptors on internal membranes during transformation of the cercariae into the schistosomulum.
Full text:
Available
Collection:
International databases
Health context:
Neglected Diseases
Health problem:
Neglected Diseases
/
Zoonoses
Database:
LILACS
Main subject:
Schistosoma mansoni
/
Skin
/
Fluorescent Dyes
/
Host-Parasite Interactions
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2010
Document type:
Article
Affiliation country:
Brazil
/
United kingdom
Institution/Affiliation country:
Instituto de Pesquisas René Rachou/BR
/
Queen's University Belfast/IE
/
University of Glasgow/GB