Brain plasticity, signal transduction and epigenesis: a missing link revealed
ARBS annu. rev. biomed. sci
; 11(n.esp): T114-T122, 20090000. ilus
Article
in English
| LILACS
| ID: lil-560454
Responsible library:
BR33.1
ABSTRACT
It has been long thought that the brain reorganizes itself in response to environmental needs. Sensory experiences coded in action potentials are the mean by which information on the surroundings is introduced into neuronal networks. The information approaching the brain in the form of electrochemical codes must then be translated in biochemical, epigenetic and genetic ones. Only until recently we have begun understanding the underpinning of such informational transformations and how this process is expressed as neuronal plastic responses. Central for our comprehension of this matter is the finding that signals transduction cascades can modify gene expression by remodeling the chromatin through epigenetic mechanisms. Hence, chromatin remodeling seems to be the process by which experiences are imprinted.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Signal Transduction
/
Gene Expression
/
Epigenesis, Genetic
/
Neuronal Plasticity
Language:
English
Journal:
ARBS annu. rev. biomed. sci
Journal subject:
Biology
Year:
2009
Document type:
Article
Affiliation country:
Mexico
Institution/Affiliation country:
Instituto Nacional de Pediatría/MX
/
Universidad Michoacana de San Nicolás de Hidalgo/MX
/
Universidad Nacional Autónoma de México/MX