Alteraciones de las lipoproteínas de alta y baja densidad en pacientes coronarios con C-LDL en meta pero C-HDL y triglicéridos anormales / High and low density lipoprotein abnormalities in coronary patients with LDL-C at target and uncontrolled HDL-C and triglycerides
Arch. cardiol. Méx
; 78(1): 30-39, ene.-mar. 2008.
Article
in Spanish
| LILACS
| ID: lil-567785
Responsible library:
BR1.1
ABSTRACT
OBJECTIVE:
To investigate the high density lipoprotein (HDL) subclasses distribution and chemical composition, as well as low density lipoprotein (LDL) size and LDL oxidation, in coronary male patients treated with statins, that had LDL-cholesterol levels at target (< 100 mg/dL), but whose HDL-cholesterol (< 40 mg/dL) and triglycerides (TG > or = 150 mg/dL) levels were abnormal. The control group was formed by statin treated coronary male patients with LDL-C below 100 mg/dL and normal HDL-C and TG levels. MATERIAL ANDMETHODS:
HDL subclasses and LDL size were determined by gradient gel electrophoresis. LDL susceptibility to oxidation was determined by measuring lag phase duration, after adding the oxidant agent.RESULTS:
Compared with the control group (n = 35), patients with low HDL-C + high TG (n = 34) showed significantly lower proportions of large HDL and higher proportions of small HDL particles. In addition, these patients had abnormal HDL composition, smaller LDL size, and higher LDL susceptibility to oxidation (p < 0.05 for all).CONCLUSIONS:
Coronary patients with optimal LDL-C levels on statin therapy but with low HDL-C and high TG, have HDL and LDL abnormalities that have been shown to be associated with a higher risk of new coronary events.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Triglycerides
/
Coronary Disease
/
Lipoproteins, HDL
/
Cholesterol, HDL
/
Lipoproteins, LDL
/
Cholesterol, LDL
Limits:
Humans
/
Male
Language:
Spanish
Journal:
Arch. cardiol. Méx
Journal subject:
Cardiology
Year:
2008
Document type:
Article
Affiliation country:
Mexico
Institution/Affiliation country:
Instituto Nacional de Cardiologia Ignacio Chavez/MX