Genetic and biological characterization of a densovirus isolate that affects dengue virus infection
Mem. Inst. Oswaldo Cruz
; 106(3): 285-292, May 2011. ilus, tab
Article
in English
| LILACS
| ID: lil-589036
Responsible library:
BR1.1
ABSTRACT
Brevidensoviruses have an encapsidated, single-stranded DNA genome that predominantly has a negative polarity. In recent years, they have received particular attention due to their potential role in the biological control of pathogenic arboviruses and to their unnoticed presence in cell cultures as contaminants. In addition, brevidensoviruses may also be useful as viral vectors. This study describes the first genetic and biological characterization of a mosquito densovirus that was isolated in Brazil; moreover, we examined the phylogenetic relationship between this isolate and the other brevidensoviruses. We further demonstrate that this densovirus has the potential to be used to biologically control dengue virus (DENV) infection with in vitro co-infection experiments. The present study provides evidence that this densovirus isolate is a fast-spreading virus that affects cell growth and DENV infection.
Full text:
Available
Collection:
International databases
Health context:
SDG3 - Health and Well-Being
/
Neglected Diseases
/
SDG3 - Target 3.3 End transmission of communicable diseases
Health problem:
Target 3.3: End transmission of communicable diseases
/
Dengue
/
Dengue
Database:
LILACS
Main subject:
Densovirus
/
Dengue Virus
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2011
Document type:
Article
Affiliation country:
Brazil
/
United States
Institution/Affiliation country:
Instituto Carlos Chagas-Fiocruz/BR
/
Mississippi State University/US
/
Universidade Federal do Rio de Janeiro/BR