Location matters: the endoplasmic reticulum and protein trafficking in dendrites
Biol. Res
; 44(1): 17-23, 2011. ilus
Article
in English
| LILACS
| ID: lil-591860
Responsible library:
BR1.1
ABSTRACT
Neurons are highly polarized, but the trafficking mechanisms that operate in these cells and the topological organization of their secretory organelles are still poorly understood. Particularly incipient is our knowledge of the role of the neuronal endoplasmic reticulum. Here we review the current understanding of the endoplasmic reticulum in neurons, its structure, composition, dendritic distribution and dynamics. We also focus on the trafficking of proteins through the dendritic endoplasmic reticulum, emphasizing the relevance of transport, retention, assembly of multi-subunit protein complexes and export. We additionally discuss the roles of the dendritic endoplasmic reticulum in synaptic plasticity.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Cell Membrane Permeability
/
Dendrites
/
Endoplasmic Reticulum
/
Membrane Proteins
/
Neuronal Plasticity
Limits:
Humans
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2011
Document type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Universidad de Chile/CL