Malaria-related anaemia: a Latin American perspective
Mem. Inst. Oswaldo Cruz
; 106(supl.1): 91-104, Aug. 2011. tab
Article
in English
| LILACS
| ID: lil-597249
Responsible library:
BR1.1
ABSTRACT
Malaria is the most important parasitic disease worldwide, responsible for an estimated 225 million clinical cases each year. It mainly affects children, pregnant women and non-immune adults who frequently die victims of cerebral manifestations and anaemia. Although the contribution of the American continent to the global malaria burden is only around 1.2 million clinical cases annually, there are 170 million inhabitants living at risk of malaria transmission in this region. On the African continent, where Plasmodium falciparum is the most prevalent human malaria parasite, anaemia is responsible for about half of the malaria-related deaths. Conversely, in Latin America (LA), malaria-related anaemia appears to be uncommon, though there is a limited knowledge about its real prevalence. This may be partially explained by several factors, including that the overall malaria burden in LA is significantly lower than that of Africa, that Plasmodium vivax, the predominant Plasmodium species in the region, appears to display a different clinical spectrus and most likely because better health services in LA prevent the development of severe malaria cases. With the aim of contributing to the understanding of the real importance of malaria-related anaemia in LA, we discuss here a revision of the available literature on the subject and the usefulness of experimental animal models, including New World monkeys, particularly for the study of the mechanisms involved in the pathogenesis of malaria.
Full text:
Available
Collection:
International databases
Health context:
Neglected Diseases
Health problem:
Malaria
/
Neglected Diseases
Database:
LILACS
Main subject:
Malaria, Vivax
/
Malaria, Falciparum
/
Anemia
Type of study:
Prognostic study
/
Risk factors
Limits:
Animals
/
Female
/
Humans
/
Pregnancy
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2011
Document type:
Article
/
Project document
Affiliation country:
Brazil
/
Colombia
/
United States
Institution/Affiliation country:
Caucaseco Scientific Research Center/CO
/
Fundação de Medicina Tropical Dr Heitor Vieira Dourado/BR
/
Universidad de Antioquia/CO
/
Yerkes National Primate Research Centre/US