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Optical coherence tomography evaluation of retinal nerve fiber layer in longitudinally extensive transverse myelitis / Avaliação da camada de fibras nervosas da retina na mielite transversal longitudinalmente extensa usando tomografia de coerência óptica
Moura, Frederico C; Fernandes, Danilo B; Apóstolos-Pereira, Samira L; Callegaro, Dagoberto; Marchiori, Paulo E; Monteiro, Mário L. R.
Affiliation
  • Moura, Frederico C; University of São Paulo Medical School. Laboratory of Ophthalmological Investigations. São Paulo. BR
  • Fernandes, Danilo B; University of São Paulo Medical School. Laboratory of Ophthalmological Investigations. São Paulo. BR
  • Apóstolos-Pereira, Samira L; University of São Paulo Medical School. Department of Neurology. São Paulo. BR
  • Callegaro, Dagoberto; University of São Paulo Medical School. Department of Neurology. São Paulo. BR
  • Marchiori, Paulo E; University of São Paulo Medical School. Department of Neurology. São Paulo. BR
  • Monteiro, Mário L. R; University of São Paulo Medical School. Laboratory of Ophthalmological Investigations. São Paulo. BR
Arq. neuropsiquiatr ; 69(1): 69-73, Feb. 2011. tab
Article in English | LILACS | ID: lil-598349
Responsible library: BR1.1
ABSTRACT

OBJECTIVE:

To compare optical coherence tomography (OCT) measurements on the retinal nerve fiber layer (RNFL) of healthy controls and patients with longitudinally extensive transverse myelitis (LETM) without previous optic neuritis.

METHOD:

Twenty-six eyes from 26 patients with LETM and 26 control eyes were subjected to automated perimetry and OCT for comparison of RNFL measurements.

RESULTS:

The mean deviation values from perimetry were significantly lower in patients with LETM than in controls (p<0.0001). RNFL measurements in the nasal quadrant and in the 3-o'clock segment were significantly smaller in LETM eyes than in controls. (p=0.04 and p=0.006, respectively). No significantly differences in other RNFL measurements were found.

CONCLUSION:

Patients with LETM may present localized RNFL loss, particularly on the nasal side of the optic disc, associated with slight visual field defects, even in the absence of previous episodes of optic neuritis. These findings emphasize the fact that patients with LETM may experience attacks of subclinical optic nerve damage.
RESUMO

OBJETIVO:

Comparar as medidas da camada de fibras nervosas da retina (CFNR) usando a tomografia de coerência óptica (TCO) em indivíduos normais e pacientes com mielite transversal longitudinalmente extensa (MTLE) sem episódio prévio de neurite óptica.

MÉTODO:

Vinte e seis olhos de 26 pacientes com MTLE e 26 olhos normais foram submetidos à campimetria computadorizada e TCO para comparação das medidas da CFNR.

RESULTADOS:

Valores do parâmetro desvio médio da campimetria computadorizada foram significativamente menores nos pacientes com MTLE do que nos controles (p<0,001). Medidas da CFNR no quadrante nasal e no segmento 3 horas foram significativamente menores nos olhos dos pacientes com MTLE do que nos olhos normais (p=0,04 e p=0,006, respectivamente). Não foi encontrada diferença significante nas outras medidas da CFNR avaliadas.

CONCLUSÃO:

Pacientes com MTLE podem apresentar perda localizada da CFNR, particularmente na região nasal do disco óptico, associada a defeitos discretos de campo visual, mesmo na ausência de episódio prévio de neurite óptica. Estes achados sugerem que pacientes com MTLE podem apresentar acometimento subclínico do nervo óptico.
Subject(s)


Full text: Available Collection: International databases Database: LILACS Main subject: Retinal Diseases / Retinal Neurons / Myelitis, Transverse / Nerve Fibers Type of study: Observational study / Risk factors Limits: Adolescent / Adult / Aged / Female / Humans / Male Language: English Journal: Arq. neuropsiquiatr Journal subject: Neurology / Psychiatry Year: 2011 Document type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: University of São Paulo Medical School/BR

Full text: Available Collection: International databases Database: LILACS Main subject: Retinal Diseases / Retinal Neurons / Myelitis, Transverse / Nerve Fibers Type of study: Observational study / Risk factors Limits: Adolescent / Adult / Aged / Female / Humans / Male Language: English Journal: Arq. neuropsiquiatr Journal subject: Neurology / Psychiatry Year: 2011 Document type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: University of São Paulo Medical School/BR
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