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Evaluation of effects of dichloromethane fraction from Platonia insignis on pilocarpine-induced seizures
Costa Júnior, Joaquim S. da; Ferraz, Alexandre de B. F; Feitosa, Chistiane Mendes; Citó, Antonia Maria das Graças Lopes; Saffi, Jenifer; Freitas, Rivelilson Mendes de.
Affiliation
  • Costa Júnior, Joaquim S. da; Universidade Luterana do Brasil. Laboratório de Toxicologia Genética. BR
  • Ferraz, Alexandre de B. F; Universidade Luterana do Brasil. Laboratório de Toxicologia Genética. BR
  • Feitosa, Chistiane Mendes; Instituto Federal do Piaui. Departamento de Química. BR
  • Citó, Antonia Maria das Graças Lopes; Instituto Federal do Piaui. Departamento de Química. BR
  • Saffi, Jenifer; Universidade Federal de Ciências da Saúde de Porto Alegre. Departamento de Ciências Básicas da Saúde. BR
  • Freitas, Rivelilson Mendes de; Instituto Federal do Piaui. Departamento de Bioquímica e Farmacologia. BR
Rev. bras. farmacogn ; 21(6): 1104-1110, Nov.-Dec. 2011. graf, tab
Article in English | LILACS | ID: lil-602304
Responsible library: BR1.1
ABSTRACT
The objective of present study was to evaluate the antioxidant and anticonvulsant activities of dichloromethane fraction (DMF) from Platonia insignis Mart., Clusiaceae. The DMF from P. insignis (2 mg/kg) was tested by intraperitoneal (i.p.) to evaluate effects on lipid peroxidation level, nitrite formation, as well as on locomotor and anticonvulsant activities. Wistar rats were treated with, (saline/Tween 80 0.5 percent, i.p., control group), DMF (2 mg/kg, i.p., DMF group), pilocarpine (400 mg/kg, i.p., P400 group), or the combination of DMF (2 mg/kg, i.p.) and pilocarpine (400 mg/kg, i.p., DMF plus P400). After the treatments all groups were observed for 24 h. In P400 group rats there was a decrease in the motor activity when compared with control group. In DMF plus P400 co-administered rats was observed an increase in motor activity when compared with P400 group. In P400 group rats there was a significant increase in lipid peroxidation and nitrite levels. In DMF plus P400 co-administered rats, antioxidant treatment significantly reduced the lipid peroxidation level and nitrite content after seizures. Previous findings strongly support the hypothesis that oxidative stress occurs in rat striatum during pilocarpine-induced seizures, and our results imply that strong neuprotective effect on this brain region could be achieved using DMF from P. insignis.


Full text: Available Collection: International databases Database: LILACS Language: English Journal: Rev. bras. farmacogn Journal subject: Pharmacy Year: 2011 Document type: Article Affiliation country: Brazil Institution/Affiliation country: Instituto Federal do Piaui/BR / Universidade Federal de Ciências da Saúde de Porto Alegre/BR / Universidade Luterana do Brasil/BR

Full text: Available Collection: International databases Database: LILACS Language: English Journal: Rev. bras. farmacogn Journal subject: Pharmacy Year: 2011 Document type: Article Affiliation country: Brazil Institution/Affiliation country: Instituto Federal do Piaui/BR / Universidade Federal de Ciências da Saúde de Porto Alegre/BR / Universidade Luterana do Brasil/BR
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