Estatura final (EF) em síndrome de Turner (ST): experiência de 76 casos acompanhados na Unidade de Endocrinologia Pediátrica do Hospital de Clínicas da Universidade Federal do Paraná / Final height (FH) in Turner syndrome (TS): experience of 76 cases followed at the Pediatric Endocrinology Unit, Hospital de Clinicas, Federal University of Paraná
Arq. bras. endocrinol. metab
; 55(5): 318-325, June 2011. ilus, tab
Article
in Portuguese
| LILACS
| ID: lil-604161
Responsible library:
BR1.1
RESUMO
Objetivo:
Relatar estatura final (EF) em 76 pacientes com síndrome de Turner (ST).Materiais e métodos:
Revisão de prontuários e avaliação dos escores z da estatura alvo (EA) e EF segundo o NCHS/CDC/2000 e da EF segundo Lyon e cols.Resultados:
Pacientes foram classificados em três grupos A (n = 16), tratamento com estrogênios e progestágenos; B (n = 21), tratamento com oxandrolona; C (n = 39), tratamento com hormônio de crescimento (GH) e oxandrolona. Não houve diferença no escore z da EA entre os grupos e no escore z da EF entre A e B. O escore z da EF do grupo C foi maior que o dos outros grupos, maior que 2 DP segundo Lyon e no percentil 3 da curva NCHS/CDC. Análise de regressão múltipla mostrou tipo de tratamento (p < 0,001) e estatura materna (p = 0,02) como fatores que mais influenciaram a EF.Conclusão:
GH mais OX e estatura materna contribuíram significativamente para aumento da EF na ST.ABSTRACT
Objective:
To report the final height (FH) of 76 patients with Turner syndrome (TS). Materials andmethods:
Review of the files and calculation of z scores of target height (TH), and FH according to NCHS/CDC/2000 and FH according to Lyon and cols.Results:
Patients were classified in three groups A (n = 16), treatment with estrogens and progestogens; B (n = 21), treatment with oxandrolone (OX); C (n = 39), growth hormone (GH) plus OX. The z score of TH was not different among the groups and z score of FH was not different between A e B. Z score of FH of group C was greater than the other groups, > 2SDS of Lyon's curve and fitted on the 3rd percentile of NCHS/CDC. Multiple regression analysis showed type of treatment (p < 0.001) and maternal height (p = 0.02) as most influencing factors on FH.Conclusion:
GH plus OX and maternal height contributed significantly to enhance FH of TS patients.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Progestins
/
Turner Syndrome
/
Body Height
/
Human Growth Hormone
/
Estrogens
/
Androgens
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
Language:
Portuguese
Journal:
Arq. bras. endocrinol. metab
Journal subject:
Endocrinology
/
Metabolism
Year:
2011
Document type:
Article