STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg
Braz. j. med. biol. res
; 44(11): 1080-1087, Nov. 2011. ilus
Article
in English
| LILACS
| ID: lil-604269
Responsible library:
BR1.1
ABSTRACT
Highly efficient mechanisms regulate intracellular calcium (Ca2+) levels. The recent discovery of new components linking intracellular Ca2+ stores to plasma membrane Ca2+ entry channels has brought new insight into the understanding of Ca2+ homeostasis. Stromal interaction molecule 1 (STIM1) was identified as a Ca2+ sensor essential for Ca2+ store depletion-triggered Ca2+ influx. Orai1 was recognized as being an essential component for the Ca2+ release-activated Ca2+ (CRAC) channel. Together, these proteins participate in store-operated Ca2+ channel function. Defective regulation of intracellular Ca2+ is a hallmark of several diseases. In this review, we focus on Ca2+ regulation by the STIM1/Orai1 pathway and review evidence that implicates STIM1/Orai1 in several pathological conditions including cardiovascular and pulmonary diseases, among others.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Calcium Channels
/
Calcium
/
Calcium Signaling
/
Membrane Proteins
/
Neoplasm Proteins
Type of study:
Prognostic study
/
Systematic review
Limits:
Humans
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2011
Document type:
Article
Affiliation country:
Brazil
/
United States
Institution/Affiliation country:
Georgia Heath Science University/US
/
Universidade de São Paulo/BR