Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon
Genet. mol. biol
; 34(4): 539-545, 2011. tab
Article
in English
| LILACS
| ID: lil-605936
Responsible library:
BR1.1
ABSTRACT
Complement receptor 1 (CR1) gene polymorphisms that are associated with Knops blood group antigens may influence the binding of Plasmodium parasites to erythrocytes, thereby affecting susceptibility to malaria. The aim of this study was to evaluate the genotype and allele and haplotype frequencies of single-nucleotide polymorphisms (SNPs) of Knops blood group antigens and examine their association with susceptibility to malaria in an endemic area of Brazil. One hundred and twenty-six individuals from the Brazilian Amazon were studied. The CR1-genomic fragment was amplified by PCR and six SNPs and haplotypes were identified after DNA sequence analysis. Allele and haplotype frequencies revealed that the Kn b allele and H8 haplotype were possibly associated with susceptibility to Plasmodium falciparum. The odds ratios were reasonably high, suggesting a potentially important association between two Knops blood antigens (Kn b and KAM+) that confer susceptibility to P. falciparum in individuals from the Brazilian Amazon.
Full text:
Available
Collection:
International databases
Health context:
Neglected Diseases
Health problem:
Malaria
/
Neglected Diseases
Database:
LILACS
Main subject:
Polymorphism, Genetic
/
Population Characteristics
/
ABO Blood-Group System
/
Haplotypes
/
Brazil
/
Receptors, Complement 3b
/
Amazonian Ecosystem
/
Malaria
Type of study:
Prognostic study
/
Risk factors
Aspects:
Social determinants of health
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Genet. mol. biol
Journal subject:
Genetics
Year:
2011
Document type:
Article
/
Project document
Affiliation country:
Brazil
/
United States
Institution/Affiliation country:
Hemocentro do Amazonas/BR
/
Iowa State University/US
/
Santa Casa de São Paulo/BR
/
Universidade Federal de São Paulo/BR
/
Universidade de São Paulo/BR