Síndrome de lisis tumoral en pediatría / Tumoral lysis syndrome in pediatrics
Rev. chil. pediatr
; 82(4): 344-350, ago. 2011. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-608838
Responsible library:
CL1.1
ABSTRACT
Tumor lysis syndrome is a metabolic emergency resulting from the rapid and massive destruction of tumor cells, spontaneously or secondary to cytolytic therapy for cancer. This results in a huge imbalance of internal environment by releasing large amounts of intracellular contents into the interstitial and intravascular space, with serious clinical consequences or even death. The pediatric population is especially at risk of tumor lysis syndrome because it has a high rate of fast-growing tumors, such as those of hematologic origin. Proper recognition of the risk factors that can cause this syndrome, as well as specific prevention and treatment has substantially decreased complications and improved survival in these patients.
RESUMEN
El síndrome de lisis tumoral es una emergencia metabólica derivada de la rápida y masiva destrucción de células tumorales en forma espontánea o secundaria a terapia citolítica del cáncer. Esta situación produce un enorme desequilibrio del medio interno al liberarse grandes cantidades de contenido intracelular al espacio intersticial e intravascular, con consecuencias clínicas serias e incluso mortales. La población pediátrica está especialmente expuesta a sufrir síndrome de lisis tumoral ya que presenta una tasa elevada de tumores de rápido crecimiento, como son los de orígenes hematológicos. El adecuado reconocimiento de los factores de riesgo que pueden causar este síndrome, así como su prevención y tratamiento específicos han disminuido sustancialmente las complicaciones y mejorado la sobrevida de estos pacientes.
Full text:
Available
Collection:
International databases
Health context:
Sustainable Health Agenda for the Americas
Health problem:
Goal 9: Noncommunicable diseases and mental health
Database:
LILACS
Main subject:
Tumor Lysis Syndrome
Type of study:
Etiology study
/
Risk factors
Limits:
Child
/
Humans
Language:
Spanish
Journal:
Rev. chil. pediatr
Journal subject:
Pediatrics
Year:
2011
Document type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Clínica Alemana de Santiago/CL