Metabolic evaluation of young women with congenital adrenal hyperplasia / Avaliação metabólica em mulheres jovens com hiperplasia adrenal congênita
Arq. bras. endocrinol. metab
; 55(8): 646-652, nov. 2011. tab
Article
in En
| LILACS
| ID: lil-610468
Responsible library:
BR1.1
ABSTRACT
OBJECTIVE:
To evaluate insulin resistance and lipid profile in women with congenital adrenal hyperplasia (CAH) caused by classical 21-hydroxylase deficiency (21OHD), and their association with body mass index (BMI) and corticosteroid dosage. SUBJECTS ANDMETHODS:
We assessed BMI, waist circumference, current glucocorticoid dosage, glucose, insulin and lipid profile in eighteen young women (mean ± SD, 19.3 ± 3.0 years) with 21OHD CAH.RESULTS:
BMI was normal in 12 patients, 5 of them were overweight, and 1 was obese. Waist circumference was high in 7 patients. Fasting insulin and HOMA-IR were elevated in seven and eight patients, respectively. Total cholesterol and triglycerides were high in only two patients, and HDL-cholesterol was low in four. Insulin resistance was not associated with BMI, waist circumference or glucocorticoid dose.CONCLUSIONS:
Young women with 21OHD CAH had infrequent dyslipidemia, but had a higher prevalence of insulin resistance and central obesity, that were independent of BMI or corticosteroid dosage.RESUMO
OBJETIVO:
Avaliar a presença de resistência insulínica e dislipidemia em mulheres com hiperplasia adrenal congênita (HAC) por deficiência da 21-hidroxilase (21OHD) e investigar a associação com índice de massa corporal (IMC) e dose de glicocorticoide prescrita. PACIENTES EMÉTODOS:
Em 18 mulheres jovens (média ± DP, 19,3 ± 3,0 anos), avaliamos IMC, circunferência abdominal, dose de glicocorticoide, glicemia, insulinemia e perfil lipídico.RESULTADOS:
O IMC foi normal em 12 pacientes; 5 apresentavam sobrepeso e 1 apresentou obesidade. Circunferência abdominal estava aumentada em 7 pacientes. Insulinemia de jejum e HOMA-IR estavam elevados em 7 e 8 pacientes, respectivamente. Apenas 2 pacientes apresentaram aumento de colesterol total ou de triglicérides e 4, diminuição dos níveis de HDL-colesterol. Resistência insulínica não apresentou associação com IMC, circunferência abdominal ou dose de glicocorticoide prescrita.CONCLUSÃO:
Mulheres jovens com CAH 21OHD apresentaram pouca dislipidemia, mas tiveram alta prevalência de resistência insulínica e obesidade central, independentemente do IMC e da dose de glicocorticoide prescrita.Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Insulin Resistance
/
Body Mass Index
/
Adrenal Hyperplasia, Congenital
/
Glucocorticoids
/
Lipids
Type of study:
Diagnostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Female
/
Humans
Language:
En
Journal:
Arq. bras. endocrinol. metab
Journal subject:
ENDOCRINOLOGIA
/
METABOLISMO
Year:
2011
Document type:
Article
Affiliation country:
Brazil