Intravenous thrombolysis is more effective in ischemic cardioembolic strokes than in non-cardioembolic? / A trombólise endovenosa é mais eficaz nos acidentes vasculares cerebrais isquêmicos cardioembólicos do que nos não cardioembólicos?
Arq. neuropsiquiatr
; Arq. neuropsiquiatr;69(6): 905-909, Dec. 2011. tab
Article
in En
| LILACS
| ID: lil-612630
Responsible library:
BR1.1
ABSTRACT
It was suggested that intravenous thrombolysis (IT) leads to larger extent recanalization in cardioembolic stroke. In this work we assess if this has beneficial clinical traduction. METHOD:
We evaluated 177 patients undergoing IT, which were categorized into cardioembolic (CE) and non-cardioembolic (NCE). National Institutes of Health Stroke Scale (NIHSS) and modified Rankin scale were compared.RESULTS:
The mean age was 67.4±12.01 and 53.8 percent were male. The mean NIHSS was 14 (admission), 9 (24 h) and 6 (discharge), similar in subgroups. The difference between NIHSS at admission and 24 hours was 4.17±4.92 (CE 4.08±4.71; NCE 4.27±5.17, p=0.900) and at admission and discharge there was an average difference of 6.74±5.58 (CE 6.97±5.68; NCE 6.49±5.49, p=0.622). The mRS at discharge and 3 months was not significantly different by subtype, although individuals whose event was NCE are more independent at 3 months.CONCLUSION:
Ours findings argue against a specific paper of IT in CE. It can result from heterogeneity of NCE group.RESUMO
Alguns estudos sugerem que a trombólise endovenosa (TE) conduz a melhor recanalização nos acidentes vasculares cerebrais isquêmicos (AVCI) cardioembólicos. Neste trabalho questionamos se isto terá tradução em benefício clínico. MÉTODO:
Avaliamos 177 doentes submetidos a TE, os quais foram categorizados como cardioembólicos (CE) e não cardioembólicos (NCE). Compararam-se a National Institutes of Health Stroke Scale (NIHSS) e escala de Rankin modificada.RESULTADOS:
A idade média foi 67,4±12,01 e 53,8 por cento eram homens. NIHSS média foi 14 (admissão), 9 (24 h), 6 (alta), semelhante nos subgrupos. A diferença entre NIHSS à admissão e 24 h foi de 4,17±4,92 (CE 4,08±4,71; NCE 4,27±5,17, p=0,900) e entre a admissão e a alta de 6,74±5,58 (CE 6,97±5,68; NCE 6,49±5,49, p=0,622). A classificação na mRS não foi significativamente diferente nos subgrupos (alta e 3 meses), mas os doentes com eventos NCE estavam mais independentes aos 3 meses.CONCLUSÃO:
Os nossos resultados não documentam um papel específico da TE nos CE, o que pode resultar da heterogeneidade do grupo NCE.Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Thrombolytic Therapy
/
Stroke
Type of study:
Etiology_studies
/
Observational_studies
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
En
Journal:
Arq. neuropsiquiatr
Journal subject:
NEUROLOGIA
/
PSIQUIATRIA
Year:
2011
Document type:
Article
Affiliation country:
Brazil
/
Portugal
Country of publication:
Brazil