Efecto de las hormonas tímicas sobre la síntesis de IL-4 / Effect of thymic hormones over the synthesis of IL-4
Prensa méd. argent
; Prensa méd. argent;98(3): 133-139, 2011. tab
Article
in Es
| LILACS
| ID: lil-616804
Responsible library:
AR392.1
ABSTRACT
A thymic hormone baptized as thymostimulin coming from children aged between 5-10 years who died after car accidents was obtained by Sephadex G-50 column fractionation. This polypeptide was incubated with atopic and non-atopic human lymphocytes. The level of IL-4 in the supernatant was measured by ELISA. The atopic lymphocytes stimulated by the thymostimulin produced a great quantity of IL-4 (p>0.000001) in comparison with those coming from non-atopic patients. Thus, we postulate that thymic hormones should not be used in the treatment of allergic conditions with high levels of IL-4. The function of this polypeptide was compared with that of bovine timomodulin, which showed lower level of IL-4 (p>_ 0.001).
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Collection:
01-internacional
Database:
LILACS
Main subject:
Thymus Gland
/
Thymus Hormones
/
Enzyme-Linked Immunosorbent Assay
/
Data Interpretation, Statistical
Limits:
Child
/
Child, preschool
/
Humans
Language:
Es
Journal:
La Prensa médica argentina
/
Prensa Med Argent
/
Prensa méd. argent
Journal subject:
MEDICINA
Year:
2011
Document type:
Article
Affiliation country:
Argentina
Country of publication:
Argentina