Chest computed tomography findings in severe influenza pneumonia occurring in neutropenic cancer patients
Clinics
; 67(4): 313-318, 2012. ilus, tab
Article
in English
| LILACS
| ID: lil-623109
Responsible library:
BR1.1
ABSTRACT
OBJECTIVE:
To describe the chest computed tomography findings for severe influenza H1N1 infection in a series of hospitalized neutropenic cancer patients.METHODS:
We performed a retrospective systematic analysis of chest computed tomography scans for eight hospitalized patients with fever, neutropenia, and confirmed diagnoses of influenza H1N1. The clinical data had been prospectively collected.RESULTS:
Six of eight patients (75%) developed respiratory failure and required intensive care. Prolonged H1N1 shedding was observed in the three mechanically ventilated patients, and overall hospital mortality in our series was 25%. The most frequent computed tomography findings were ground-glass opacity (all patients), consolidation (7/8 cases), and airspace nodules (6/8 cases) that were frequently moderate or severe. Other parenchymal findings were not common. Five patients had features of pneumonia, two had computed tomography findings compatible with bronchitis and/or bronchiolitis, and one had tomographic signs of chronicity.CONCLUSION:
In this series of neutropenic patients with severe influenza H1N1 infection, chest computed tomography demonstrated mainly moderate or severe parenchymatous disease, but bronchiolitis was not a common feature. These findings associated with febrile neutropenia should elicit a diagnosis of severe viral infection.
Full text:
Available
Collection:
International databases
Health context:
SDG3 - Health and Well-Being
/
SDG3 - Target 3.3 End transmission of communicable diseases
/
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
/
SDG3 - Target 3.2 Reduce avoidable death in newborns and children under 5
Health problem:
Target 3.3: End transmission of communicable diseases
/
Target 3.2: Reduce avoidable death in newborns and children under 5
/
Pneumonia
/
Other Blood Disorders
/
Other Respiratory Diseases
/
Infections
Database:
LILACS
Main subject:
Pneumonia, Viral
/
Tomography, X-Ray Computed
/
Influenza, Human
/
Influenza A Virus, H1N1 Subtype
/
Neoplasms
/
Neutropenia
Type of study:
Diagnostic study
Limits:
Adolescent
/
Child, preschool
/
Female
/
Humans
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2012
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
D'Or Institute for Research and Education/BR
/
Federal University of Rio de Janeiro/BR
/
Instituto Nacional de Câncer/BR