Cerámicas mexicanas para cicatrización de piel / Mexican Ceramic Material for Skin Healing
Gac. méd. Méx
; Gac. méd. Méx;140(1): 7-14, ene.-feb. 2004. ilus, tab
Article
in Es
| LILACS
| ID: lil-632152
Responsible library:
MX1.1
RESUMEN
Se utilizaron 60 ratas Wistar, que fueron evaluadas a los 15, 30 y 45 días después de la cirugía. Se quitó un cuadro de piel del lomo del animal, removiendo la epidermis y la dermis hasta alcanzar la fascia muscular donde se aplicó el material de experimentación. Se usó Nitrofurazona como control positivo y ningún material como control negativo. Los materiales a probar fueron fosfatos de aluminio a los que se agregó 0.55% en peso de Zn y 0.30% en peso de Ca(0H)2 siendo éste el material A, y 0.55% en peso de Zn y 0.66% en peso de Ca(0H)2 el material B. Se trataron cinco ratas con cada material. Los objetivos del trabajo fueron la obtención de las cerámicas a probar y la evaluación de su efecto sobre el proceso de cicatrización de piel de ratas. Los materiales obtenidos fueron caracterizados con DRX. Estudios histopatológicos probaron que los mejores procesos de cicatrización de la piel se observaron en las ratas tratadas con el material A. El uso de las cerámicas AlPO para cicatrización de piel no ha sido reportado antes.
ABSTRACT
Sixty female Wistar rats were employed and divided into three experimental groups of 20 rats each. Groups were evaluated at 15, 30, and the last at 45 days after surgery. Each group was divided into four sets of five rats each. All rats were subjected to surgery; an incision of 2 x 2cm was done on the back of each animal, removing tissue until reaching muscular fascia, where the material was applied. Nitro-furazone was employed as positive control. Test materials were AlPO added with 0.55% wt of Zn; 0.30% wt of Ca(OH)2 and AlPO added with 0.55% wt of Zn and 0.66% wt of Ca(0H)2. Finally, as negative control no material was used. The object of this work was in the first place obtension of test materials and to evaluate the healing skin process in rats using AlPO enriched with Zn and Ca(0H)2; as indicated previously. Obtained materials were characterized employing XRD. Histologic studies tested showed that best healing process of dermal tissue corresponded to rats treated with AlPO added with 0.55% wt of Zn and 0.30% wt of Ca(OH)2. Use of AlPO ceramics to repair skin has not been reported previously.
Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Skin
/
Skin Physiological Phenomena
/
Wound Healing
/
Ceramics
Limits:
Animals
Country/Region as subject:
Mexico
Language:
Es
Journal:
Gac. méd. Méx
Journal subject:
MEDICINA
Year:
2004
Document type:
Article
Affiliation country:
Mexico
Country of publication:
Mexico