Falla hepática secundaria a toxicidad por tuberculostáticos: Caso clínico / Fulminant hepatic failure due to tuberculostatic drugs: Case report
Arch. argent. pediatr
; 110(3): e35-e38, mayo-jun. 2012. ilus
Article
in Spanish
| LILACS
| ID: lil-639616
Responsible library:
AR1.2
RESUMEN
La toxicidad hepática por isoniacida, sobre todo asociada a rifampicina, es un raro efecto adverso de la terapia antituberculosa. En EE.UU., es la causa de 0,2% de los trasplantes hepáticos pediátricos y del 14% de los trasplantes por toxicidad medicamentosa. Comunicamos el caso de una paciente de 10 años de edad con falla hepática fulminante que requirió trasplante hepático luego de cuarenta días de tratamiento tuberculostático con isoniacida, rifampicina y pirazinamida.
ABSTRACT
Hepatoxicity of isoniazid, mainly in association with rifampin, is a rare secondary effect of tuberculostatic treatment. In the United States, it accounts for 0.2% of all pediatric orthotropic liver transplant, and 14% of transplants for drug hepatotoxicity. We report the case of a 10 year-old patient who presented with acute liver failure requiring orthotropic liver transplant after forty days of tuberculostatic treatment with isoniazid, rifampin and pyrazinamide.
Full text:
Available
Collection:
International databases
Health context:
Neglected Diseases
Health problem:
Neglected Diseases
/
Tuberculosis
Database:
LILACS
Main subject:
Pyrazinamide
/
Rifampin
/
Liver Failure, Acute
/
Isoniazid
/
Antitubercular Agents
Limits:
Child
/
Female
/
Humans
Language:
Spanish
Journal:
Arch. argent. pediatr
Journal subject:
Pediatrics
Year:
2012
Document type:
Article
Affiliation country:
Argentina
Institution/Affiliation country:
Hospital Universitario Austral/AR