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Cuestionamiento éticos relacionados con la terapia génica para el tratamiento de enfermedades hereditarias / Ethial questioniing related to gene theraphy for inherited diseases treatment
OSORIO, JOSÉ HENRY.
Affiliation
  • OSORIO, JOSÉ HENRY; Universidad de Caldas. Manizales. CO
Rev. luna azul ; (32): 114-120, ene.-jun. 2011.
Article in Spanish | LILACS | ID: lil-639878
Responsible library: CO54.1
RESUMEN
La introducción de secuencias genéticas exógenas denominadas transgenes se denomina terapia génica, y tiene el propósito de corregir alteraciones genotípicas o fenotípicas en el organismo humano. Esta terapia puede realizarse en células somáticas o en células germinales; los cuestionamientos éticos relacionados con la terapia génica somática tienen que ver básicamente con los riesgos potenciales para la salud y el consentimiento informado, mientras que la terapia génica en células germinales tiene el potencial de afectar permanentemente a futuras generaciones de personas. Debido a que la terapia génica involucra mucho más que la simple alteración de las secuencias genéticas, esta revisión presenta los principales problemas éticos asociados con la terapia génica para enfermedades hereditarias.
ABSTRACT
The introduction of exogenous genetic sequences named transgenes is known as gene therapy and has the purpose of correcting genotypic and phenotypic alterations in the human organism. This therapy can be carried out in somatic cells or in germinal cells. The ethical questioning related to somatic gene therapy has to do basically with the potential risks for health and the informed consent while germ-line gene therapy has the potential to affect permanently future generations. Since genic therapy involves much more than the simple alteration of genetic sequences, this revision presents the main ethical problems associated with gene therapy for inherited disease.
Subject(s)

Full text: Available Collection: International databases Database: LILACS Main subject: Genetic Therapy Aspects: Ethical aspects Limits: Humans Language: Spanish Journal: Rev. luna azul Journal subject: Ecologia / Medicine / Environmental Health Year: 2011 Document type: Article Affiliation country: Colombia Institution/Affiliation country: Universidad de Caldas/CO
Full text: Available Collection: International databases Database: LILACS Main subject: Genetic Therapy Aspects: Ethical aspects Limits: Humans Language: Spanish Journal: Rev. luna azul Journal subject: Ecologia / Medicine / Environmental Health Year: 2011 Document type: Article Affiliation country: Colombia Institution/Affiliation country: Universidad de Caldas/CO
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