Té verde, fitomedicamento contra la influenza A: rol de las catequinas / Green tea, phytomedicine against influenza A: role of catechins
Bol. latinoam. Caribe plantas med. aromát
; 11(2): 106-110, mar. 2012.
Article
in Spanish
| LILACS
| ID: lil-647622
Responsible library:
CL1.1
ABSTRACT
The highly variable Influenza A is constantly changed in new forms, like avian influenza or actual pandemic swine flu, has forced to massive use of antiviral drugs. Neuraminidase inhibitors are those with acceptable risk efficacy profile. However, high variability of neuraminidase among different Influenza A viruses has resulted in viral resistance. Searching for new therapeutic resources, green tea (Camelia sinensis) has been reported to inhibit Influenza A virus replication, due to its catechines that bind to the active pocket endonuclease domain of viral RNA-dependent RNA polymerase. This enzyme is highly conserved among influenza A virus variants. So, a Camelia sinensis catechine standardized extract could become an anti endonuclease herbal drug.
RESUMEN
La constante aparición de nuevas variantes de la Influenza A, como la denominada influenza aviar y la más reciente gripe porcina, de características pandémicas, ha obligado al uso masivo de fármacos antivirales. Los únicos con un perfil riesgo eficacia aceptable son los inhibidores de la neuraminidasa. Sin embargo, la poca conservación entre la neuraminidasa de las diferentes cepas de virus Influenza A, han evidenciado resistencia viral. En la búsqueda de nuevos recursos terapéuticos, se ha reportado que el té verde (Camelia sinensis), gracias a su contenido de catequinas, puede inhibir la replicación de virus Influenza A, al unirse específicamente al bolsillo activo del dominio endonucleasa de la polimerasa de ARN dependiente de ARN viral, una enzima que posee un alto grado de conservación entre las diferentes variantes del virus de la Influenza A. Un extracto de Camelia sinensis estandarizado en catequinas podría constituirse en un fitofármaco antiendonucleasa.
Full text:
Available
Collection:
International databases
Health context:
Sustainable Health Agenda for the Americas
/
SDG3 - Health and Well-Being
Health problem:
Goal 9: Noncommunicable diseases and mental health
/
Goal 10: Communicable diseases
/
Target 3.3: End transmission of communicable diseases
/
Target 3.4: Reduce premature mortality due to noncommunicable diseases
Database:
LILACS
Main subject:
Tea
/
Catechin
/
Camellia sinensis
/
Influenza, Human
/
Influenza A Virus, H1N1 Subtype
Language:
Spanish
Journal:
Bol. latinoam. Caribe plantas med. aromát
Journal subject:
Botany
/
Medicine
/
Plantas Medicinais
/
Terapias Complementares
Year:
2012
Document type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Universidad de Chile/CL