The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine
Mem. Inst. Oswaldo Cruz
; 107(6): 820-823, set. 2012. ilus, tab
Article
in En
| LILACS
| ID: lil-649501
Responsible library:
BR1.1
ABSTRACT
The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.
Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Enzyme Inhibitors
/
Malaria
/
Methylene Blue
/
Antimalarials
Limits:
Animals
Language:
En
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
MEDICINA TROPICAL
/
PARASITOLOGIA
Year:
2012
Document type:
Article
Affiliation country:
Colombia
/
France
/
Spain
Country of publication:
Brazil