Leishmanicidal activity of fractions rich in aporphine alkaloids from Amazonian Unonopsis species
Rev. bras. farmacogn
; 22(6): 1368-1371, Nov.-Dec. 2012. ilus, tab
Article
in English
| LILACS
| ID: lil-659043
Responsible library:
BR1.1
ABSTRACT
In vitro evaluation of alkaloidal fractions of twigs, barks and leaves from two Unonopsis species, Unonopsis guatterioides R.E. Fr. and Unonopsis duckei R.E. Fr., Annonaceae, against promastigote forms of Leishmania amazonensis revealed these species as sources of substances with promising leishmanicidal potential. All alkaloidal fractions from twigs, barks and leaves of U. guatterioides were classified as highly active, with IC50 1.07, 1.90, and 2.79 mg/mL, respectively. Only the alkaloidal fraction from the twigs of U. duckei was classified as inactive.
Full text:
Available
Collection:
International databases
Database:
LILACS
Language:
English
Journal:
Rev. bras. farmacogn
Journal subject:
Pharmacy
Year:
2012
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal do Amazonas/BR