Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects
Mem. Inst. Oswaldo Cruz
; 107(supl.1): 74-78, Dec. 2012. tab
Article
in English
| LILACS
| ID: lil-659744
Responsible library:
BR1.1
ABSTRACT
This study sought to verify the correlation between leprosy types and the adverse effects of treatment drugs. This quantitative, prospective, nested study was developed at the Dona Libânia Dermatology Centre in Fortaleza, Brazil. Data were collected from November 2007-November 2008. During this period, 818 leprosy patients were diagnosed and began treatment. Forty patients with tuberculoid leprosy (TT) were selected. Twenty patients followed a standard therapy of dapsone and rifampicin and 20 were administered dapsone, rifampicin and clofazimine (U-MDT). Twenty patients with borderline lepromatous (BL) and lepromatous leprosy (LL) were also selected and treated with U-MDT. All of the subjects received six doses. With the exception of haemolytic anaemia, there was a low incidence of adverse effects in all the groups. We did not observe any differences in the incidence of haemolytic anaemia or other side effects across groups of patients with TT, BL or LL treated with U-MDT.
Full text:
Available
Collection:
International databases
Health context:
SDG3 - Health and Well-Being
/
Neglected Diseases
Health problem:
Target 3.3: End transmission of communicable diseases
/
Leprosy
/
Neglected Diseases
Database:
LILACS
Main subject:
Leprosy, Lepromatous
/
Leprosy, Tuberculoid
/
Leprosy, Multibacillary
/
Leprostatic Agents
Type of study:
Controlled clinical trial
/
Observational study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2012
Document type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Centro de Referência Dona Libania/BR