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Infecções helmínticas crônicas aumentam a susceptibilidade ao Mycobacterium tuberculosis e reduzem a eficácia da vacina BCG / Chronic helminths infections increases susceptibility to Mycobacterium tuberculosis and diminishes BCG vaccination effectiveness
Ferreira, Ana Paula; Dias, Alyria Teixeira; Alves, Caio César de Souza.
Affiliation
  • Ferreira, Ana Paula; Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. BR
  • Dias, Alyria Teixeira; Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. BR
  • Alves, Caio César de Souza; Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. BR
HU rev ; 37(4): 495-501, dez. 2011.
Article in Portuguese | LILACS | ID: lil-661239
Responsible library: BR378.1
RESUMO
A eficácia do Bacilo Calmette Guerin (BCG) é baixa e a incidência de tuberculose é elevada em áreas onde os helmintos são endêmicos. Enquanto a proteção contra a tuberculose exige forte imunidade celular, infecções helmínticas crônicas induzem respostas caracterizadas pelo perfil Th2, bem como o aumento da atividade de células T reguladoras. Portanto, infecções helmínticas crônicas poderiam modular a resposta imunológica necessária para controlar a infecção por micobactérias e/ou a eficácia da vacinação com BCG.
ABSTRACT
The effectiveness of Bacille Calmette Guerin (BCG) is low and the incidence of tuberculosis is high in areas where helminths are endemic. While protection against tuberculosis requires strong cellular immunity, chronic helminth infections induce responses characterized by Th2 profile, as well as increased T regulatory cell activity. Therefore, chronic helminth infection could modulate the immune response needed to control mycobacterial infection and/or the efficacy of vaccination against tuberculosis
Subject(s)
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Full text: Available Collection: International databases Health context: Sustainable Health Agenda for the Americas / SDG3 - Health and Well-Being / Neglected Diseases / SDG3 - Target 3.3 End transmission of communicable diseases Health problem: Goal 10: Communicable diseases / Target 3.3: End transmission of communicable diseases / Target 3.4: Reduce premature mortality due to noncommunicable diseases / Helminthiasis / Neglected Diseases / Tuberculosis / Zoonoses / Tuberculosis Database: LILACS Main subject: Tuberculosis / Mycobacterium tuberculosis Language: Portuguese Journal: HU rev Journal subject: Medicine Year: 2011 Document type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Juiz de Fora/BR
Fulltext
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Full text: Available Collection: International databases Health context: Sustainable Health Agenda for the Americas / SDG3 - Health and Well-Being / Neglected Diseases / SDG3 - Target 3.3 End transmission of communicable diseases Health problem: Goal 10: Communicable diseases / Target 3.3: End transmission of communicable diseases / Target 3.4: Reduce premature mortality due to noncommunicable diseases / Helminthiasis / Neglected Diseases / Tuberculosis / Zoonoses / Tuberculosis Database: LILACS Main subject: Tuberculosis / Mycobacterium tuberculosis Language: Portuguese Journal: HU rev Journal subject: Medicine Year: 2011 Document type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Juiz de Fora/BR