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The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats
Azevedo, Vera Lucia Fernandes de; Santos, Paulo Sergio Santana; Oliveira Jr, Gildàsio Silveira de; Módolo, Gabriel Pinheiro; Domingues, Maria Aparecida Custódio; Castiglia, Yara Marcondes Machado; Vianna, Pedro Thadeu Galvão; Vane, Luiz Antonio; Módolo, Norma Sueli Pinheiro.
Affiliation
  • Azevedo, Vera Lucia Fernandes de; UNESP. Botucatu Medical School. Postgraduate Program in Anesthesiology. Sao Paulo. BR
  • Santos, Paulo Sergio Santana; UNESP. Botucatu Medical School. Postgraduate Program in Anesthesiology. Sao Paulo. BR
  • Oliveira Jr, Gildàsio Silveira de; UNESP. Botucatu Medical School. Postgraduate Program in Anesthesiology. Sao Paulo. BR
  • Módolo, Gabriel Pinheiro; UNESP. Botucatu Medical School. Postgraduate Program in Anesthesiology. Sao Paulo. BR
  • Domingues, Maria Aparecida Custódio; UNESP. Botucatu Medical School. Postgraduate Program in Anesthesiology. Sao Paulo. BR
  • Castiglia, Yara Marcondes Machado; UNESP. Botucatu Medical School. Postgraduate Program in Anesthesiology. Sao Paulo. BR
  • Vianna, Pedro Thadeu Galvão; UNESP. Botucatu Medical School. Postgraduate Program in Anesthesiology. Sao Paulo. BR
  • Vane, Luiz Antonio; UNESP. Botucatu Medical School. Postgraduate Program in Anesthesiology. Sao Paulo. BR
  • Módolo, Norma Sueli Pinheiro; UNESP. Botucatu Medical School. Postgraduate Program in Anesthesiology. Sao Paulo. BR
Acta cir. bras ; Acta cir. bras;28(1): 5-9, jan. 2013. ilus, tab
Article in En | LILACS | ID: lil-662341
Responsible library: BR1.1
ABSTRACT

PURPOSE:

To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia.

METHODS:

Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol.

RESULTS:

Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury.

CONCLUSION:

Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion.
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Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Hydroxyethyl Starch Derivatives / Plasma Substitutes / Acute Kidney Injury / Ischemia / Isotonic Solutions / Kidney Type of study: Guideline / Prognostic_studies Limits: Animals Language: En Journal: Acta cir. bras Journal subject: Cirurgia Geral / Procedimentos Cir£rgicos Operat¢rios Year: 2013 Document type: Article / Project document Affiliation country: Brazil Country of publication: Brazil
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Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Hydroxyethyl Starch Derivatives / Plasma Substitutes / Acute Kidney Injury / Ischemia / Isotonic Solutions / Kidney Type of study: Guideline / Prognostic_studies Limits: Animals Language: En Journal: Acta cir. bras Journal subject: Cirurgia Geral / Procedimentos Cir£rgicos Operat¢rios Year: 2013 Document type: Article / Project document Affiliation country: Brazil Country of publication: Brazil