Comparing percutaneous coronary intervention and thrombolysis in patients with return of spontaneous circulation after cardiac arrest
Clinics
; 68(4): 523-529, abr. 2013. tab, graf
Article
in English
| LILACS
| ID: lil-674246
Responsible library:
BR1.1
ABSTRACT
OBJECTIVE:
To evaluate the effects of percutaneous coronary intervention and thrombolysis after restoration of spontaneous circulation in cardiac arrest patients with ST-elevation myocardial infarction using meta-analysis.METHODS:
We performed a meta-analysis of clinical studies indexed in the PUBMED, MEDLINE and EMBASE databases and published between January 1995 and October 2012. In addition, we compared the hospital discharge and neurological recovery rates between the patients who received percutaneous coronary intervention and those who received thrombolysis.RESULTS:
Twenty-four studies evaluating the effects of percutaneous coronary intervention or thrombolysis after restoration of spontaneous circulation in cardiac arrest patients with ST-elevation myocardial infarction were included. Seventeen of the 24 studies were used in this meta-analysis. All studies were used to compare percutaneous coronary intervention and thrombolysis. The meta-analysis showed that the rate of hospital discharge improved with both percutaneous coronary intervention (p<0.001) and thrombolysis (p<0.001). We also found that cardiac arrest patients with ST-elevation myocardial infarction who received thrombolysis after restoration of spontaneous circulation did not have decreased hospital discharge (p = 0.543) or neurological recovery rates (p = 0.165) compared with those who received percutaneous coronary intervention.CONCLUSION:
In cardiac arrest patients with ST-elevation myocardial infarction who achieved restoration of spontaneous circulation, both percutaneous coronary intervention and thrombolysis improved the hospital discharge rate. Furthermore, there were no significant differences in the hospital discharge and neurological recovery rates between the percutaneous coronary intervention-treated group and the thrombolysis-treated group. .
Full text:
Available
Collection:
International databases
Health context:
SDG3 - Target 3.8 Achieve universal access to health
Health problem:
Delivery Arrangements
Database:
LILACS
Main subject:
Blood Circulation
/
Thrombolytic Therapy
/
Percutaneous Coronary Intervention
/
Heart Arrest
/
Myocardial Infarction
Type of study:
Systematic review
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2013
Document type:
Article
/
Project document
Affiliation country:
China
Institution/Affiliation country:
Sun Yat-sen University/CN