Efectos de las estatinas en cáncer: ¿potencial rol en terapéutica y prevención? / Effects of statins in cancer
Rev. méd. Chile
; 141(2): 227-236, feb. 2013. ilus
Article
in Spanish
| LILACS
| ID: lil-675064
Responsible library:
CL1.1
ABSTRACT
This review explores the evidence supporting a potential benefit of statins in cancer. In particular, the lipophilic forms (i.e. lovastatin, simvastatin, or similar) would have a therapeutic but not a preventive role. The pleiotropic effects that statins possess mainly explain this phenomenon, influencing the natural history of disease and the response to currently available therapies. By inhibiting the mevalonate pathway, statins would have a systemic effect, similar to that observed in atherosclerosis, reducing the inflammatory stimuli present in the tumor micro-environment and inhibiting the activation of intracellular signaling cascades critical for proliferation, migration/invasion and metastasis of the cancer cell. Despite all this evidence, randomized trials are needed to confirm the benefit of statins on cancer, before promoting their widespread use as a therapeutic or preventive strategy for this condition.
Full text:
Available
Collection:
International databases
Health context:
Sustainable Health Agenda for the Americas
Health problem:
Goal 9: Noncommunicable diseases and mental health
Database:
LILACS
Main subject:
Hydroxymethylglutaryl-CoA Reductase Inhibitors
/
Neoplasms
Type of study:
Controlled clinical trial
/
Etiology study
Limits:
Animals
/
Humans
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2013
Document type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Pontificia Universidad Católica de Chile/CL