Immunohistochemical profile of high-grade ductal carcinoma in situ of the breast
Clinics
; 68(5): 674-678, maio 2013. tab, graf
Article
in English
| LILACS
| ID: lil-675751
Responsible library:
BR1.1
ABSTRACT
OBJECTIVE:
To determine the frequency of the immunohistochemical profiles of a series of high-grade ductal carcinoma in situ of the breast.METHODS:
One hundred and twenty-one cases of high-grade ductal carcinoma in situ, pure or associated with invasive mammary carcinoma, were identified from 2003 to 2008 and examined with immunohistochemistry for estrogen receptor, human epidermal growth factor receptor 2, cytokeratin 5, and epidermal growth factor receptor. The tumors were placed into five subgroups luminal A, luminal B, HER2, basal-like, and “not classified”.RESULTS:
The frequencies of the immunophenotypes of pure ductal carcinoma in situ were the following luminal A (24/42 cases; 57.1%), luminal B (05/42 cases; 11.9%), HER2 (07/42 cases; 16.7%), basal-like phenotype (00/42 cases; 0%), and “not classified” (06/42 cases; 14.3%). The immunophenotypes of ductal carcinoma in situ associated with invasive carcinoma were the following luminal A (46/79 cases; 58.2%), luminal B (10/79 cases; 12.7%), HER2 (06/79 cases; 7.6%), basal-like (06/79 cases; 7.6%), and “not classified” (11/79 cases; 13.9%). There was no significant difference in the immunophenotype frequencies between pure ductal carcinoma in situ and ductal carcinoma in situ associated with invasive carcinoma (p>0.05). High agreement was observed in immunophenotypes between both components (kappa=0.867).CONCLUSION:
The most common immunophenotype of pure ductal carcinoma in situ was luminal A, followed by HER2. The basal-like phenotype was observed only in ductal carcinoma in situ associated with invasive carcinoma, which had a similar phenotype. .
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Breast Neoplasms
/
Carcinoma, Ductal, Breast
/
Carcinoma, Intraductal, Noninfiltrating
Type of study:
Prognostic study
Limits:
Female
/
Humans
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2013
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Minas Gerais/BR